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Pneumonia
Respiratory
Clinical reference
Pneumonia
Pneumonia is infection of the lung parenchyma. CAP (community-acquired), HAP (hospital-acquired), VAP (ventilator-associated). PSI/PORT or CURB-65 guides admission decisions.
Terms
8
ICD-10
8
Evidence
5
Trials
8
Latest evidence
Latest evidence
Antibiotic Resistance Patterns and Hospital-acquired Infection among COVID-19 Patients Attending Intensive Care Unit: A Single-center Descriptive Study.
Exposure to antibiotics with anaerobe coverage in later life is associated with higher enteric pathobiont carriage.
Comparison of the Efficacy and Safety of Intravenous Ceftazidime-Avibactam and Intrathecal/Intraventricular Polymyxin B Sulfate in the Treatment of CNS Infections Caused by KPC-Kp in Neurosurgical Patients: A Single-Center Prospective Observational Study.
Klebsiella pneumoniae Carbapenemase-Producing Enterobacterales Infection and Colonization in a Long-Term Care Facility - Ontario, Canada, May 2024-January 2025.
Core official overview
What this condition is
What is pneumonia?Pneumonia is an infection in one or both of the lungs. It causes the air sacs of the lungs to fill up with fluid or pus. It can range from mild to severe, depending on the type of germ causing the infection, your age, and your overall health.What causes pneumonia?Bacterial, viral, and fungal infections can cause pneumonia.Bacteria are the most common cause. Bacterial pneumonia can occur on its own.…
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Recruiting clinical trials
Additional official research
A Phase 3b Randomized, Double-blind, Multi-center Study to Compare the Safety and Efficacy of Omadacycline to Moxifloxacin for Treating Adult Subjects With CABP
The primary objective of the study is to show that in Chinese adults with CABP, a course of IV/PO treatment with omadacycline has similar clinical efficacy as the with the comparator antibiotic, IV/PO moxifloxacin. The study is designed as…
Awake Prone Positioning of Patients Suffering Community Acquired Pneumonia Requiring Nasal High Flow Therapy
Community acquired pneumonia, in particular when requiring oxygen therapy because of acute hypoxemic respiratory failure and meeting acute respiratory distress syndrome (ARDS) criteria frequently leads to tracheal intubation and poor outco…
AntiThrombotic Therapy to Ameliorate Clinical Complications in Community Acquired Pneumonia
This is an international, open-label, stratified randomized controlled trial with Bayesian adaptive stopping rules to compare the effects of therapeutic-dose heparin vs. usual care pharmacological thromboprophylaxis on outcomes in patients…
Clarithromycin Treatment to Prevent Sepsis Progression in CAP (REACT)
The primary objective of the REACT randomized clinical trial (RCT) is to optimize the clinical benefit from adjunctive clarithromycin treatment shown in the ACCESS trial and to provide evidence for the clinical benefit of early start of ad…
Customized Antibiotic Treatment Duration Among Hospitalized Patients With Moderately Severe Community-Acquired Pneumonia
The primary objective of the study is to evaluate if the efficacy of an experimental strategy on antibiotic treatment duration based on stopping treatment when stability criteria are reached after at least 48 h of treatment, is non-inferio…
High-dose Inhalations of Nitric Oxide in the Treatment of Pneumonia
This is a multicenter, prospective randomized controlled trial. At least 2 but no more than 5 centers are expected to participate in the study. The primary objective is to test the hypothesis that the addition of high-dose inhaled nitric o…
Definition of Sub-phenotypes of Pneumonia Based on the Respiratory Microbiome Composition to Predict Microbial and Clinical Treatment Failures
Background: Pneumonia remains a leading cause of antibiotic consumption globally, contributing significantly to the burden of antimicrobial resistance (AMR). The respiratory microbiome plays a crucial role in the emergence of AMR and thera…
Comparing Antibiotic Treatment Strategies for Children With Pneumonia in Outpatient Settings: (STAMPP)
The goal of this clinical trial is to determine if a "watch and wait" antibiotic strategy, called Safety Net Antibiotic Prescribing (SNAP), can safely reduce unnecessary antibiotic use while ensuring that children diagnosed with community-…
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Pneumonia
What is pneumonia?Pneumonia is an infection in one or both of the lungs. It causes the air sacs of the lungs to fill up with fluid or pus. It can range from mild to severe, depending on the type of germ causing the infection, your age, and your overall health.What causes pneumonia?Bacterial, viral, and fungal infections can cause pneumonia.Bacteria are the most common cause. Bacterial pneumonia can occur on its own.…
Pneumocystis Infections
What is Pneumocystis jirovecii?Pneumocystis jirovecii is a fungus that is common throughout the world. Many people have been exposed to it as children. Some people have the fungus in their lungs. If you are healthy, it usually will not make you sick. But it can make you sick if you have a weakened immune system, for example if you:Have HIVHave an autoimmune diseaseHave cancerHave a chronic (long-lasting) lung diseas…
Legionnaires' Disease
What is Legionnaires' Disease? Legionnaires' disease is a serious type of pneumonia caused by Legionella bacteria. The disease got its name when a group of people at an American Legion convention became ill with this type of pneumonia.Legionella is found naturally in freshwater, such as lakes and rivers. It can also be found in soil. But people usually only get sick from it when if it grows and spreads in man-made w…
HIV and Infections
Having HIV/AIDS weakens your body's immune system. It destroys the white blood cells that fight infection. This puts you at risk for opportunistic infections (OIs). OIs are serious infections that take advantage of your weak immune system. These infections are less common and less severe in healthy people.There are many types of OIs:Bacterial infections, including tuberculosis and a serious related disease, Mycobact…