Tumor Lysis Syndrome

Body Systems › Oncology › Tumor Lysis Syndrome
Cancer Clinical reference

Tumor Lysis Syndrome

TLS: metabolic emergency from rapid malignant cell death releasing intracellular contents. Hyperuricemia, hyperkalemia, hyperphosphatemia, hypocalcemia. Most common: high-grade lymphoma, ALL. Prevention is key.

TLS tumor lysis syndrome tumor lysis
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ICD-10 quick links

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E88.3 Tumor lysis syndrome
Common tests

Tests performed

BMP q4-8h (K+, phosphorus, Ca, creatinine) Uric acid CBC LDH (elevated — marker of lysis) ECG (hyperkalemia) Urine output monitoring
Common medications

Recognize the drug and the class

Aggressive IV hydration (2-3 L/m²/day) — urine alkalinization controversial Allopurinol (prophylaxis — high risk patients) Rasburicase (recombinant urate oxidase — severe/very high risk; avoid in G6PD deficiency) Treat hyperkalemia (Calcium gluconate, Insulin/D50, Kayexalate) Dialysis (severe renal failure/hyperkalemia)
Related nursing diagnoses

NANDA diagnoses & care plans

Use these direct links to open nursing diagnoses and care-plan support related to Tumor Lysis Syndrome.

Risk for Electrolyte Imbalance Deficient Fluid Volume Anxiety Risk for Cardiac Dysrhythmia