Error message
User warning: mkdir(): Permission Denied in Drupal\Component\PhpStorage\FileStorage->createDirectory() (line 125 of core/lib/Drupal/Component/PhpStorage/FileStorage.php).
Drupal\Component\PhpStorage\FileStorage->createDirectory() (Line: 73) Drupal\Component\PhpStorage\FileStorage->ensureDirectory() (Line: 66) Drupal\Component\PhpStorage\MTimeProtectedFastFileStorage->save() (Line: 116) Drupal\Core\Template\TwigPhpStorageCache->write() (Line: 410) Twig\Environment->loadTemplate() (Line: 370) Twig\Environment->load() (Line: 35) Drupal\Core\Template\TwigThemeEngine->renderTemplate() (Line: 428) Drupal\Core\Theme\ThemeManager->render() (Line: 500) Drupal\Core\Render\Renderer->doRender() (Line: 253) Drupal\Core\Render\Renderer->doRenderRoot() (Line: 143) Drupal\Core\Render\Renderer->{closure:Drupal\Core\Render\Renderer::renderInIsolation():142}() (Line: 634) Drupal\Core\Render\Renderer::{closure:Drupal\Core\Render\Renderer::executeInRenderContext():634}() Fiber->start() (Line: 635) Drupal\Core\Render\Renderer->executeInRenderContext() (Line: 142) Drupal\Core\Render\Renderer->renderInIsolation() (Line: 169) Drupal\Core\Render\Renderer->doRenderPlaceholder() (Line: 206) Drupal\Core\Render\Renderer->renderPlaceholder() (Line: 797) Drupal\Core\Render\Renderer->replacePlaceholders() (Line: 265) Drupal\Core\Render\Renderer->doRenderRoot() (Line: 143) Drupal\Core\Render\Renderer->{closure:Drupal\Core\Render\Renderer::renderInIsolation():142}() (Line: 634) Drupal\Core\Render\Renderer::{closure:Drupal\Core\Render\Renderer::executeInRenderContext():634}() Fiber->start() (Line: 635) Drupal\Core\Render\Renderer->executeInRenderContext() (Line: 142) Drupal\Core\Render\Renderer->renderInIsolation() (Line: 113) Drupal\Core\Render\Renderer->renderRoot() (Line: 253) Drupal\Core\Render\HtmlResponseAttachmentsProcessor->renderPlaceholders() (Line: 74) Drupal\big_pipe\Render\BigPipeResponseAttachmentsProcessor->processAttachments() (Line: 106) Drupal\canvas\Render\ImportMapResponseAttachmentsProcessor->processAttachments() (Line: 45) Drupal\Core\EventSubscriber\HtmlResponseSubscriber->onRespond() (Line: 246) Symfony\Component\EventDispatcher\EventDispatcher::{closure:Symfony\Component\EventDispatcher\EventDispatcher::optimizeListeners():241}() (Line: 206) Symfony\Component\EventDispatcher\EventDispatcher->callListeners() (Line: 56) Symfony\Component\EventDispatcher\EventDispatcher->dispatch() (Line: 216) Symfony\Component\HttpKernel\HttpKernel->filterResponse() (Line: 204) Symfony\Component\HttpKernel\HttpKernel->handleRaw() (Line: 76) Symfony\Component\HttpKernel\HttpKernel->handle() (Line: 53) Drupal\Core\StackMiddleware\Session->handle() (Line: 48) Drupal\Core\StackMiddleware\KernelPreHandle->handle() (Line: 28) Drupal\Core\StackMiddleware\ContentLength->handle() (Line: 32) Drupal\big_pipe\StackMiddleware\ContentLength->handle() (Line: 203) Drupal\page_cache\StackMiddleware\PageCache->fetch() (Line: 140) Drupal\page_cache\StackMiddleware\PageCache->lookup() (Line: 89) Drupal\page_cache\StackMiddleware\PageCache->handle() (Line: 48) Drupal\Core\StackMiddleware\ReverseProxyMiddleware->handle() (Line: 51) Drupal\Core\StackMiddleware\NegotiationMiddleware->handle() (Line: 53) Drupal\Core\StackMiddleware\AjaxPageState->handle() (Line: 54) Drupal\Core\StackMiddleware\StackedHttpKernel->handle() (Line: 745) Drupal\Core\DrupalKernel->handle() (Line: 19)User warning: mkdir(): Permission Denied in Drupal\Component\PhpStorage\FileStorage->createDirectory() (line 125 of core/lib/Drupal/Component/PhpStorage/FileStorage.php).
Drupal\Component\PhpStorage\FileStorage->createDirectory() (Line: 73) Drupal\Component\PhpStorage\FileStorage->ensureDirectory() (Line: 66) Drupal\Component\PhpStorage\MTimeProtectedFastFileStorage->save() (Line: 116) Drupal\Core\Template\TwigPhpStorageCache->write() (Line: 410) Twig\Environment->loadTemplate() (Line: 370) Twig\Environment->load() (Line: 35) Drupal\Core\Template\TwigThemeEngine->renderTemplate() (Line: 428) Drupal\Core\Theme\ThemeManager->render() (Line: 500) Drupal\Core\Render\Renderer->doRender() (Line: 230) Drupal\Core\Render\Renderer->render() (Line: 242) Drupal\Core\Render\MainContent\HtmlRenderer->{closure:Drupal\Core\Render\MainContent\HtmlRenderer::prepare():235}() (Line: 634) Drupal\Core\Render\Renderer::{closure:Drupal\Core\Render\Renderer::executeInRenderContext():634}() Fiber->start() (Line: 635) Drupal\Core\Render\Renderer->executeInRenderContext() (Line: 235) Drupal\Core\Render\MainContent\HtmlRenderer->prepare() (Line: 131) Drupal\Core\Render\MainContent\HtmlRenderer->renderResponse() (Line: 90) Drupal\Core\EventSubscriber\MainContentViewSubscriber->onViewRenderArray() (Line: 246) Symfony\Component\EventDispatcher\EventDispatcher::{closure:Symfony\Component\EventDispatcher\EventDispatcher::optimizeListeners():241}() (Line: 206) Symfony\Component\EventDispatcher\EventDispatcher->callListeners() (Line: 56) Symfony\Component\EventDispatcher\EventDispatcher->dispatch() (Line: 188) Symfony\Component\HttpKernel\HttpKernel->handleRaw() (Line: 76) Symfony\Component\HttpKernel\HttpKernel->handle() (Line: 53) Drupal\Core\StackMiddleware\Session->handle() (Line: 48) Drupal\Core\StackMiddleware\KernelPreHandle->handle() (Line: 28) Drupal\Core\StackMiddleware\ContentLength->handle() (Line: 32) Drupal\big_pipe\StackMiddleware\ContentLength->handle() (Line: 118) Drupal\page_cache\StackMiddleware\PageCache->pass() (Line: 92) Drupal\page_cache\StackMiddleware\PageCache->handle() (Line: 48) Drupal\Core\StackMiddleware\ReverseProxyMiddleware->handle() (Line: 51) Drupal\Core\StackMiddleware\NegotiationMiddleware->handle() (Line: 53) Drupal\Core\StackMiddleware\AjaxPageState->handle() (Line: 54) Drupal\Core\StackMiddleware\StackedHttpKernel->handle() (Line: 745) Drupal\Core\DrupalKernel->handle() (Line: 19)User warning: mkdir(): Permission Denied in Drupal\Component\PhpStorage\FileStorage->createDirectory() (line 125 of core/lib/Drupal/Component/PhpStorage/FileStorage.php).
Drupal\Component\PhpStorage\FileStorage->createDirectory() (Line: 73) Drupal\Component\PhpStorage\FileStorage->ensureDirectory() (Line: 66) Drupal\Component\PhpStorage\MTimeProtectedFastFileStorage->save() (Line: 116) Drupal\Core\Template\TwigPhpStorageCache->write() (Line: 410) Twig\Environment->loadTemplate() (Line: 370) Twig\Environment->load() (Line: 35) Drupal\Core\Template\TwigThemeEngine->renderTemplate() (Line: 428) Drupal\Core\Theme\ThemeManager->render() (Line: 500) Drupal\Core\Render\Renderer->doRender() (Line: 230) Drupal\Core\Render\Renderer->render() (Line: 162) Drupal\Core\Render\MainContent\HtmlRenderer->{closure:Drupal\Core\Render\MainContent\HtmlRenderer::renderResponse():157}() (Line: 634) Drupal\Core\Render\Renderer::{closure:Drupal\Core\Render\Renderer::executeInRenderContext():634}() Fiber->start() (Line: 635) Drupal\Core\Render\Renderer->executeInRenderContext() (Line: 157) Drupal\Core\Render\MainContent\HtmlRenderer->renderResponse() (Line: 90) Drupal\Core\EventSubscriber\MainContentViewSubscriber->onViewRenderArray() (Line: 246) Symfony\Component\EventDispatcher\EventDispatcher::{closure:Symfony\Component\EventDispatcher\EventDispatcher::optimizeListeners():241}() (Line: 206) Symfony\Component\EventDispatcher\EventDispatcher->callListeners() (Line: 56) Symfony\Component\EventDispatcher\EventDispatcher->dispatch() (Line: 188) Symfony\Component\HttpKernel\HttpKernel->handleRaw() (Line: 76) Symfony\Component\HttpKernel\HttpKernel->handle() (Line: 53) Drupal\Core\StackMiddleware\Session->handle() (Line: 48) Drupal\Core\StackMiddleware\KernelPreHandle->handle() (Line: 28) Drupal\Core\StackMiddleware\ContentLength->handle() (Line: 32) Drupal\big_pipe\StackMiddleware\ContentLength->handle() (Line: 118) Drupal\page_cache\StackMiddleware\PageCache->pass() (Line: 92) Drupal\page_cache\StackMiddleware\PageCache->handle() (Line: 48) Drupal\Core\StackMiddleware\ReverseProxyMiddleware->handle() (Line: 51) Drupal\Core\StackMiddleware\NegotiationMiddleware->handle() (Line: 53) Drupal\Core\StackMiddleware\AjaxPageState->handle() (Line: 54) Drupal\Core\StackMiddleware\StackedHttpKernel->handle() (Line: 745) Drupal\Core\DrupalKernel->handle() (Line: 19)User warning: mkdir(): Permission Denied in Drupal\Component\PhpStorage\FileStorage->createDirectory() (line 125 of core/lib/Drupal/Component/PhpStorage/FileStorage.php).
Drupal\Component\PhpStorage\FileStorage->createDirectory() (Line: 73) Drupal\Component\PhpStorage\FileStorage->ensureDirectory() (Line: 66) Drupal\Component\PhpStorage\MTimeProtectedFastFileStorage->save() (Line: 116) Drupal\Core\Template\TwigPhpStorageCache->write() (Line: 410) Twig\Environment->loadTemplate() (Line: 370) Twig\Environment->load() (Line: 35) Drupal\Core\Template\TwigThemeEngine->renderTemplate() (Line: 428) Drupal\Core\Theme\ThemeManager->render() (Line: 500) Drupal\Core\Render\Renderer->doRender() (Line: 230) Drupal\Core\Render\Renderer->render() (Line: 501) Drupal\Core\Template\TwigExtension->escapeFilter() (Line: 96) __TwigTemplate_1542e28ecd23eb9f51b3cf19a0f0d78b->doDisplay() (Line: 402) Twig\Template->yield() (Line: 386) Twig\Template->render() (Line: 51) Twig\TemplateWrapper->render() (Line: 35) Drupal\Core\Template\TwigThemeEngine->renderTemplate() (Line: 428) Drupal\Core\Theme\ThemeManager->render() (Line: 500) Drupal\Core\Render\Renderer->doRender() (Line: 230) Drupal\Core\Render\Renderer->render() (Line: 162) Drupal\Core\Render\MainContent\HtmlRenderer->{closure:Drupal\Core\Render\MainContent\HtmlRenderer::renderResponse():157}() (Line: 634) Drupal\Core\Render\Renderer::{closure:Drupal\Core\Render\Renderer::executeInRenderContext():634}() Fiber->start() (Line: 635) Drupal\Core\Render\Renderer->executeInRenderContext() (Line: 157) Drupal\Core\Render\MainContent\HtmlRenderer->renderResponse() (Line: 90) Drupal\Core\EventSubscriber\MainContentViewSubscriber->onViewRenderArray() (Line: 246) Symfony\Component\EventDispatcher\EventDispatcher::{closure:Symfony\Component\EventDispatcher\EventDispatcher::optimizeListeners():241}() (Line: 206) Symfony\Component\EventDispatcher\EventDispatcher->callListeners() (Line: 56) Symfony\Component\EventDispatcher\EventDispatcher->dispatch() (Line: 188) Symfony\Component\HttpKernel\HttpKernel->handleRaw() (Line: 76) Symfony\Component\HttpKernel\HttpKernel->handle() (Line: 53) Drupal\Core\StackMiddleware\Session->handle() (Line: 48) Drupal\Core\StackMiddleware\KernelPreHandle->handle() (Line: 28) Drupal\Core\StackMiddleware\ContentLength->handle() (Line: 32) Drupal\big_pipe\StackMiddleware\ContentLength->handle() (Line: 118) Drupal\page_cache\StackMiddleware\PageCache->pass() (Line: 92) Drupal\page_cache\StackMiddleware\PageCache->handle() (Line: 48) Drupal\Core\StackMiddleware\ReverseProxyMiddleware->handle() (Line: 51) Drupal\Core\StackMiddleware\NegotiationMiddleware->handle() (Line: 53) Drupal\Core\StackMiddleware\AjaxPageState->handle() (Line: 54) Drupal\Core\StackMiddleware\StackedHttpKernel->handle() (Line: 745) Drupal\Core\DrupalKernel->handle() (Line: 19)User warning: mkdir(): Permission Denied in Drupal\Component\PhpStorage\FileStorage->createDirectory() (line 125 of core/lib/Drupal/Component/PhpStorage/FileStorage.php).
Drupal\Component\PhpStorage\FileStorage->createDirectory() (Line: 73) Drupal\Component\PhpStorage\FileStorage->ensureDirectory() (Line: 66) Drupal\Component\PhpStorage\MTimeProtectedFastFileStorage->save() (Line: 116) Drupal\Core\Template\TwigPhpStorageCache->write() (Line: 410) Twig\Environment->loadTemplate() (Line: 370) Twig\Environment->load() (Line: 35) Drupal\Core\Template\TwigThemeEngine->renderTemplate() (Line: 428) Drupal\Core\Theme\ThemeManager->render() (Line: 556) Drupal\Core\Render\Renderer->doRender() (Line: 230) Drupal\Core\Render\Renderer->render() (Line: 501) Drupal\Core\Template\TwigExtension->escapeFilter() (Line: 77) __TwigTemplate_71870a835705e73bfa6156daf8f36212->doDisplay() (Line: 402) Twig\Template->yield() (Line: 386) Twig\Template->render() (Line: 51) Twig\TemplateWrapper->render() (Line: 35) Drupal\Core\Template\TwigThemeEngine->renderTemplate() (Line: 428) Drupal\Core\Theme\ThemeManager->render() (Line: 500) Drupal\Core\Render\Renderer->doRender() (Line: 230) Drupal\Core\Render\Renderer->render() (Line: 501) Drupal\Core\Template\TwigExtension->escapeFilter() (Line: 96) __TwigTemplate_1542e28ecd23eb9f51b3cf19a0f0d78b->doDisplay() (Line: 402) Twig\Template->yield() (Line: 386) Twig\Template->render() (Line: 51) Twig\TemplateWrapper->render() (Line: 35) Drupal\Core\Template\TwigThemeEngine->renderTemplate() (Line: 428) Drupal\Core\Theme\ThemeManager->render() (Line: 500) Drupal\Core\Render\Renderer->doRender() (Line: 230) Drupal\Core\Render\Renderer->render() (Line: 162) Drupal\Core\Render\MainContent\HtmlRenderer->{closure:Drupal\Core\Render\MainContent\HtmlRenderer::renderResponse():157}() (Line: 634) Drupal\Core\Render\Renderer::{closure:Drupal\Core\Render\Renderer::executeInRenderContext():634}() Fiber->start() (Line: 635) Drupal\Core\Render\Renderer->executeInRenderContext() (Line: 157) Drupal\Core\Render\MainContent\HtmlRenderer->renderResponse() (Line: 90) Drupal\Core\EventSubscriber\MainContentViewSubscriber->onViewRenderArray() (Line: 246) Symfony\Component\EventDispatcher\EventDispatcher::{closure:Symfony\Component\EventDispatcher\EventDispatcher::optimizeListeners():241}() (Line: 206) Symfony\Component\EventDispatcher\EventDispatcher->callListeners() (Line: 56) Symfony\Component\EventDispatcher\EventDispatcher->dispatch() (Line: 188) Symfony\Component\HttpKernel\HttpKernel->handleRaw() (Line: 76) Symfony\Component\HttpKernel\HttpKernel->handle() (Line: 53) Drupal\Core\StackMiddleware\Session->handle() (Line: 48) Drupal\Core\StackMiddleware\KernelPreHandle->handle() (Line: 28) Drupal\Core\StackMiddleware\ContentLength->handle() (Line: 32) Drupal\big_pipe\StackMiddleware\ContentLength->handle() (Line: 118) Drupal\page_cache\StackMiddleware\PageCache->pass() (Line: 92) Drupal\page_cache\StackMiddleware\PageCache->handle() (Line: 48) Drupal\Core\StackMiddleware\ReverseProxyMiddleware->handle() (Line: 51) Drupal\Core\StackMiddleware\NegotiationMiddleware->handle() (Line: 53) Drupal\Core\StackMiddleware\AjaxPageState->handle() (Line: 54) Drupal\Core\StackMiddleware\StackedHttpKernel->handle() (Line: 745) Drupal\Core\DrupalKernel->handle() (Line: 19)User warning: mkdir(): Permission Denied in Drupal\Component\PhpStorage\FileStorage->createDirectory() (line 125 of core/lib/Drupal/Component/PhpStorage/FileStorage.php).
Drupal\Component\PhpStorage\FileStorage->createDirectory() (Line: 73) Drupal\Component\PhpStorage\FileStorage->ensureDirectory() (Line: 66) Drupal\Component\PhpStorage\MTimeProtectedFastFileStorage->save() (Line: 116) Drupal\Core\Template\TwigPhpStorageCache->write() (Line: 410) Twig\Environment->loadTemplate() (Line: 370) Twig\Environment->load() (Line: 35) Drupal\Core\Template\TwigThemeEngine->renderTemplate() (Line: 428) Drupal\Core\Theme\ThemeManager->render() (Line: 500) Drupal\Core\Render\Renderer->doRender() (Line: 513) Drupal\Core\Render\Renderer->doRender() (Line: 230) Drupal\Core\Render\Renderer->render() (Line: 501) Drupal\Core\Template\TwigExtension->escapeFilter() (Line: 166) __TwigTemplate_71870a835705e73bfa6156daf8f36212->doDisplay() (Line: 402) Twig\Template->yield() (Line: 386) Twig\Template->render() (Line: 51) Twig\TemplateWrapper->render() (Line: 35) Drupal\Core\Template\TwigThemeEngine->renderTemplate() (Line: 428) Drupal\Core\Theme\ThemeManager->render() (Line: 500) Drupal\Core\Render\Renderer->doRender() (Line: 230) Drupal\Core\Render\Renderer->render() (Line: 501) Drupal\Core\Template\TwigExtension->escapeFilter() (Line: 96) __TwigTemplate_1542e28ecd23eb9f51b3cf19a0f0d78b->doDisplay() (Line: 402) Twig\Template->yield() (Line: 386) Twig\Template->render() (Line: 51) Twig\TemplateWrapper->render() (Line: 35) Drupal\Core\Template\TwigThemeEngine->renderTemplate() (Line: 428) Drupal\Core\Theme\ThemeManager->render() (Line: 500) Drupal\Core\Render\Renderer->doRender() (Line: 230) Drupal\Core\Render\Renderer->render() (Line: 162) Drupal\Core\Render\MainContent\HtmlRenderer->{closure:Drupal\Core\Render\MainContent\HtmlRenderer::renderResponse():157}() (Line: 634) Drupal\Core\Render\Renderer::{closure:Drupal\Core\Render\Renderer::executeInRenderContext():634}() Fiber->start() (Line: 635) Drupal\Core\Render\Renderer->executeInRenderContext() (Line: 157) Drupal\Core\Render\MainContent\HtmlRenderer->renderResponse() (Line: 90) Drupal\Core\EventSubscriber\MainContentViewSubscriber->onViewRenderArray() (Line: 246) Symfony\Component\EventDispatcher\EventDispatcher::{closure:Symfony\Component\EventDispatcher\EventDispatcher::optimizeListeners():241}() (Line: 206) Symfony\Component\EventDispatcher\EventDispatcher->callListeners() (Line: 56) Symfony\Component\EventDispatcher\EventDispatcher->dispatch() (Line: 188) Symfony\Component\HttpKernel\HttpKernel->handleRaw() (Line: 76) Symfony\Component\HttpKernel\HttpKernel->handle() (Line: 53) Drupal\Core\StackMiddleware\Session->handle() (Line: 48) Drupal\Core\StackMiddleware\KernelPreHandle->handle() (Line: 28) Drupal\Core\StackMiddleware\ContentLength->handle() (Line: 32) Drupal\big_pipe\StackMiddleware\ContentLength->handle() (Line: 118) Drupal\page_cache\StackMiddleware\PageCache->pass() (Line: 92) Drupal\page_cache\StackMiddleware\PageCache->handle() (Line: 48) Drupal\Core\StackMiddleware\ReverseProxyMiddleware->handle() (Line: 51) Drupal\Core\StackMiddleware\NegotiationMiddleware->handle() (Line: 53) Drupal\Core\StackMiddleware\AjaxPageState->handle() (Line: 54) Drupal\Core\StackMiddleware\StackedHttpKernel->handle() (Line: 745) Drupal\Core\DrupalKernel->handle() (Line: 19)User warning: mkdir(): Permission Denied in Drupal\Component\PhpStorage\FileStorage->createDirectory() (line 125 of core/lib/Drupal/Component/PhpStorage/FileStorage.php).
Drupal\Component\PhpStorage\FileStorage->createDirectory() (Line: 73) Drupal\Component\PhpStorage\FileStorage->ensureDirectory() (Line: 66) Drupal\Component\PhpStorage\MTimeProtectedFastFileStorage->save() (Line: 116) Drupal\Core\Template\TwigPhpStorageCache->write() (Line: 410) Twig\Environment->loadTemplate() (Line: 370) Twig\Environment->load() (Line: 35) Drupal\Core\Template\TwigThemeEngine->renderTemplate() (Line: 428) Drupal\Core\Theme\ThemeManager->render() (Line: 500) Drupal\Core\Render\Renderer->doRender() (Line: 230) Drupal\Core\Render\Renderer->render() (Line: 501) Drupal\Core\Template\TwigExtension->escapeFilter() (Line: 139) __TwigTemplate_033accae3f1ee663fc609d06659d9dce->block_content() (Line: 446) Twig\Template->yieldBlock() (Line: 115) __TwigTemplate_033accae3f1ee663fc609d06659d9dce->doDisplay() (Line: 402) Twig\Template->yield() (Line: 386) Twig\Template->render() (Line: 51) Twig\TemplateWrapper->render() (Line: 35) Drupal\Core\Template\TwigThemeEngine->renderTemplate() (Line: 428) Drupal\Core\Theme\ThemeManager->render() (Line: 500) Drupal\Core\Render\Renderer->doRender() (Line: 513) Drupal\Core\Render\Renderer->doRender() (Line: 230) Drupal\Core\Render\Renderer->render() (Line: 501) Drupal\Core\Template\TwigExtension->escapeFilter() (Line: 166) __TwigTemplate_71870a835705e73bfa6156daf8f36212->doDisplay() (Line: 402) Twig\Template->yield() (Line: 386) Twig\Template->render() (Line: 51) Twig\TemplateWrapper->render() (Line: 35) Drupal\Core\Template\TwigThemeEngine->renderTemplate() (Line: 428) Drupal\Core\Theme\ThemeManager->render() (Line: 500) Drupal\Core\Render\Renderer->doRender() (Line: 230) Drupal\Core\Render\Renderer->render() (Line: 501) Drupal\Core\Template\TwigExtension->escapeFilter() (Line: 96) __TwigTemplate_1542e28ecd23eb9f51b3cf19a0f0d78b->doDisplay() (Line: 402) Twig\Template->yield() (Line: 386) Twig\Template->render() (Line: 51) Twig\TemplateWrapper->render() (Line: 35) Drupal\Core\Template\TwigThemeEngine->renderTemplate() (Line: 428) Drupal\Core\Theme\ThemeManager->render() (Line: 500) Drupal\Core\Render\Renderer->doRender() (Line: 230) Drupal\Core\Render\Renderer->render() (Line: 162) Drupal\Core\Render\MainContent\HtmlRenderer->{closure:Drupal\Core\Render\MainContent\HtmlRenderer::renderResponse():157}() (Line: 634) Drupal\Core\Render\Renderer::{closure:Drupal\Core\Render\Renderer::executeInRenderContext():634}() Fiber->start() (Line: 635) Drupal\Core\Render\Renderer->executeInRenderContext() (Line: 157) Drupal\Core\Render\MainContent\HtmlRenderer->renderResponse() (Line: 90) Drupal\Core\EventSubscriber\MainContentViewSubscriber->onViewRenderArray() (Line: 246) Symfony\Component\EventDispatcher\EventDispatcher::{closure:Symfony\Component\EventDispatcher\EventDispatcher::optimizeListeners():241}() (Line: 206) Symfony\Component\EventDispatcher\EventDispatcher->callListeners() (Line: 56) Symfony\Component\EventDispatcher\EventDispatcher->dispatch() (Line: 188) Symfony\Component\HttpKernel\HttpKernel->handleRaw() (Line: 76) Symfony\Component\HttpKernel\HttpKernel->handle() (Line: 53) Drupal\Core\StackMiddleware\Session->handle() (Line: 48) Drupal\Core\StackMiddleware\KernelPreHandle->handle() (Line: 28) Drupal\Core\StackMiddleware\ContentLength->handle() (Line: 32) Drupal\big_pipe\StackMiddleware\ContentLength->handle() (Line: 118) Drupal\page_cache\StackMiddleware\PageCache->pass() (Line: 92) Drupal\page_cache\StackMiddleware\PageCache->handle() (Line: 48) Drupal\Core\StackMiddleware\ReverseProxyMiddleware->handle() (Line: 51) Drupal\Core\StackMiddleware\NegotiationMiddleware->handle() (Line: 53) Drupal\Core\StackMiddleware\AjaxPageState->handle() (Line: 54) Drupal\Core\StackMiddleware\StackedHttpKernel->handle() (Line: 745) Drupal\Core\DrupalKernel->handle() (Line: 19)User warning: mkdir(): Permission Denied in Drupal\Component\PhpStorage\FileStorage->createDirectory() (line 125 of core/lib/Drupal/Component/PhpStorage/FileStorage.php).
Drupal\Component\PhpStorage\FileStorage->createDirectory() (Line: 73) Drupal\Component\PhpStorage\FileStorage->ensureDirectory() (Line: 66) Drupal\Component\PhpStorage\MTimeProtectedFastFileStorage->save() (Line: 116) Drupal\Core\Template\TwigPhpStorageCache->write() (Line: 410) Twig\Environment->loadTemplate() (Line: 370) Twig\Environment->load() (Line: 35) Drupal\Core\Template\TwigThemeEngine->renderTemplate() (Line: 428) Drupal\Core\Theme\ThemeManager->render() (Line: 556) Drupal\Core\Render\Renderer->doRender() (Line: 230) Drupal\Core\Render\Renderer->render() (Line: 501) Drupal\Core\Template\TwigExtension->escapeFilter() (Line: 96) __TwigTemplate_1542e28ecd23eb9f51b3cf19a0f0d78b->doDisplay() (Line: 402) Twig\Template->yield() (Line: 386) Twig\Template->render() (Line: 51) Twig\TemplateWrapper->render() (Line: 35) Drupal\Core\Template\TwigThemeEngine->renderTemplate() (Line: 428) Drupal\Core\Theme\ThemeManager->render() (Line: 500) Drupal\Core\Render\Renderer->doRender() (Line: 230) Drupal\Core\Render\Renderer->render() (Line: 162) Drupal\Core\Render\MainContent\HtmlRenderer->{closure:Drupal\Core\Render\MainContent\HtmlRenderer::renderResponse():157}() (Line: 634) Drupal\Core\Render\Renderer::{closure:Drupal\Core\Render\Renderer::executeInRenderContext():634}() Fiber->start() (Line: 635) Drupal\Core\Render\Renderer->executeInRenderContext() (Line: 157) Drupal\Core\Render\MainContent\HtmlRenderer->renderResponse() (Line: 90) Drupal\Core\EventSubscriber\MainContentViewSubscriber->onViewRenderArray() (Line: 246) Symfony\Component\EventDispatcher\EventDispatcher::{closure:Symfony\Component\EventDispatcher\EventDispatcher::optimizeListeners():241}() (Line: 206) Symfony\Component\EventDispatcher\EventDispatcher->callListeners() (Line: 56) Symfony\Component\EventDispatcher\EventDispatcher->dispatch() (Line: 188) Symfony\Component\HttpKernel\HttpKernel->handleRaw() (Line: 76) Symfony\Component\HttpKernel\HttpKernel->handle() (Line: 53) Drupal\Core\StackMiddleware\Session->handle() (Line: 48) Drupal\Core\StackMiddleware\KernelPreHandle->handle() (Line: 28) Drupal\Core\StackMiddleware\ContentLength->handle() (Line: 32) Drupal\big_pipe\StackMiddleware\ContentLength->handle() (Line: 118) Drupal\page_cache\StackMiddleware\PageCache->pass() (Line: 92) Drupal\page_cache\StackMiddleware\PageCache->handle() (Line: 48) Drupal\Core\StackMiddleware\ReverseProxyMiddleware->handle() (Line: 51) Drupal\Core\StackMiddleware\NegotiationMiddleware->handle() (Line: 53) Drupal\Core\StackMiddleware\AjaxPageState->handle() (Line: 54) Drupal\Core\StackMiddleware\StackedHttpKernel->handle() (Line: 745) Drupal\Core\DrupalKernel->handle() (Line: 19)
Hepatic / Biliary System
Liver/Biliary overview
Hepatic / Biliary System
Liver, biliary, and pancreatic conditions, evidence, coding, and nursing diagnoses.
Conditions
Major liver/biliary conditions
Select a condition
Liver/Biliary
6 sections
HBV
Hepatitis B (HBV): DNA virus transmitted sexually, perinatally, bloodborne. Acute: 95% adults clear. Chronic (HBsAg >6 months): cirrhosis/HCC risk. Effective vaccine available. Antivirals achieve viral suppression.
HBV
hepatitis B
chronic hepatitis B
Overview
ICD-10
Evidence
Trials
Tests Meds
Open condition →
Liver/Biliary
6 sections
HCV
Hepatitis C (HCV): RNA virus, mainly bloodborne. 75-85% become chronic → cirrhosis → HCC. Direct-acting antivirals (DAAs) achieve >95% cure rates (SVR12). All chronic HCV patients should be treated.
HCV
hepatitis C
chronic hepatitis C
Overview
ICD-10
Evidence
Trials
Tests Meds
Open condition →
Liver/Biliary
6 sections
NAFLD/NASH
NAFLD: fat in liver without significant alcohol use. NASH (nonalcoholic steatohepatitis): NAFLD + inflammation/fibrosis. Leading cause of cirrhosis worldwide. Resmetirom FDA-approved 2024 for MASH.
NAFLD
NASH
MAFLD
Overview
ICD-10
Evidence
Trials
Tests Meds
Open condition →
Liver/Biliary
6 sections
ALF
ALF: rapid liver dysfunction (coagulopathy + encephalopathy) in patient without prior liver disease. Most common cause in US: acetaminophen overdose. N-acetylcysteine and liver transplant evaluation critical.
ALF
acute liver failure
fulminant hepatic failure
Overview
ICD-10
Evidence
Trials
Tests Meds
Open condition →
Liver/Biliary
6 sections
Cholecystitis
Acute cholecystitis: gallbladder inflammation from cystic duct obstruction by gallstone (95%) or acalculous (5%). Murphy sign: inspiratory arrest with RUQ palpation. Laparoscopic cholecystectomy is treatment.
cholecystitis
acute cholecystitis
gallbladder inflammation
Overview
ICD-10
Evidence
Trials
Tests Meds
Open condition →
Nursing diagnoses & care plans
Related nursing diagnoses
Related tool
NANDA
Care plans
Nursing Diagnoses & Care Plans
Open the NANDA tool to review nursing diagnoses and care-plan concepts related to liver/biliary conditions.
Open NANDA tool →