Vaso-occlusive crisis (VOC): severe pain from ischemia in bones, chest, abdomen. Acute chest syndrome (ACS) — infiltrate + chest pain/fever — is life-threatening. Analgesia within 30 minutes.
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What is sickle cell disease (SCD)?Sickle cell disease (SCD) is a group of inherited red blood cell disorders. If you have SCD, there is a problem with your hemoglobin. Hemoglobin is a protein in red blood cells that carries oxygen throughout the body. With SCD, the hemoglobin forms into stiff rods within the red blood cells. This changes the shape of the red blood cells. The cells are supposed to be disc-shaped, but…
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The purpose of this study is to learn more about the feasibility of oral ketamine for the treatment of painful sickle-cell crises in children and adolescents as a supplement to intravenous (IV) opioids. There is a need for improved non-opi…
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