SIADH

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Endocrine Clinical reference

SIADH

SIADH (Syndrome of Inappropriate Antidiuretic Hormone) causes hyponatremia from excess ADH. Urine osmolality >100 mOsm/kg + urine Na >40. Causes: CNS, pulmonary, medications, malignancy.

SIADH syndrome of inappropriate antidiuretic hormone euvolemic hyponatremia
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Latest evidence

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Common tests

Tests performed

Serum sodium (low) Serum osmolality (low <280) Urine osmolality (>100) Urine sodium (>40) TSH (exclude hypothyroidism) Morning cortisol (exclude adrenal insufficiency)
Common medications

Recognize the drug and the class

Fluid restriction (primary treatment: 800-1000 mL/day) Hypertonic 3% NaCl (severe symptomatic — correct ≤10 mEq/24h) Salt tablets + Loop diuretic Tolvaptan (Samsca — hospital only, liver risk) Demeclocycline (chronic SIADH)
Related nursing diagnoses

NANDA diagnoses & care plans

Use these direct links to open nursing diagnoses and care-plan support related to SIADH.

Excess Fluid Volume Risk for Injury (CNS symptoms) Deficient Knowledge