Cardiovascular
Clinical reference
Infective Endocarditis
Infective endocarditis is infection of the endocardial surface, typically heart valves. Diagnosed by Duke criteria. IV antibiotics 4–6 weeks; surgery in 50% of cases.
IE
endocarditis
bacterial endocarditis
SBE
subacute bacterial endocarditis
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Core official overview
What this condition is
What is endocarditis?Endocarditis is sometimes called infective endocarditis. It's a rare but life-threatening inflammation of the lining inside your heart's chambers and valves (the endocardium).Endocarditis is usually caused by germs that get into your bloodstream and travel to your heart. Once they get inside your heart, the germs can attach to the lining or get trapped in the valves. They start to grow, causing…
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Recruiting clinical trials
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RECRUITING
PHASE3
NCT06870409
Infective endocarditis (IE) is an endocardial lesion caused by bacterial and/or fungal infection that most commonly affects the heart valves and/or the endocardium around implanted intracardiac devices. In general, IE is classified as a ra…
RECRUITING
PHASE4
NCT07523646
Infective endocarditis (IE) is a bacterial infection of the heart valves, inserted material or surrounding struc-tures and is associated with a high morbidity and mortality. In patients with IE, anemia is considered to result from the unde…
RECRUITING
NA
NCT07511673
This randomized, multicenter, open-label trial evaluates whether preoperative dental screening improves outcomes in patients undergoing surgical or transcatheter cardiac valve intervention. Participants are randomized 1:1 to preoperative d…
RECRUITING
NA
NCT06704048
How does health develop after Infective endocarditis (IE)? Can the health of patients with IE be improved by participation in the physical exercise training within cardiac rehabilitation program? Participants will: * Answer digitally surve…
RECRUITING
NA
NCT05989152
In patients with prosthetic valve endocarditis (PVE) and pathological valvular FDG uptake on the initial FDG-PET and not referred to valve replacement at the acute phase, the study will assess whether FDG-PET is able to identify those at i…
RECRUITING
N/A
NCT06403839
In Odense University Hospital preoperative dental screening (PDS) protocol for patients treated with surgical valve replacement was changed from mandatory to targeted PDS to from march 2024. The investigators will therefore compare the ris…
RECRUITING
PHASE3
NCT07345325
The primary objective of this study is to demonstrate that a rifampin-free regimen is non-inferior to the rifampin-containing regimen in terms of all-cause mortality in staphylococcal prosthetic valve endocarditis within 6 months after ran…
RECRUITING
N/A
NCT03211975
Infectious endocarditis (IE) is the localization and proliferation of blood-borne germs in the endocardium. It remains a complicated disease to manage due to its low incidence, diagnostic difficulties, the change in epidemiology in recent…
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Endocarditis
What is endocarditis?Endocarditis is sometimes called infective endocarditis. It's a rare but life-threatening inflammation of the lining inside your heart's chambers and valves (the endocardium).Endocarditis is usually caused by germs that get into your bloodstream and travel to your heart. Once they get inside your heart, the germs can attach to the lining or get trapped in the valves. They start to grow, causing…
Congenital Heart Defects
What are congenital heart defects?Congenital heart defects (CHDs) are problems with the structure of the heart. "Congenital" means that that the problems are present at birth. These defects happen when a fetus's heart doesn't develop normally during pregnancy. Congenital heart defects are the most common type of birth defect.Congenital heart defects can change the way the heart pumps blood. They may make blood flow…
Heart Valve Diseases
What are heart valve diseases?Heart valve disease happens when one or more of your heart valves don't work well.Your heart has four valves: the tricuspid, pulmonary, mitral, and aortic valves. The valves have flaps that open and close. The flaps make sure that blood flows in the right direction through your heart and to the rest of your body. When your heart beats, the flaps open to let blood through. Between heartb…
Staphylococcal Infections
What are Staphylococcal (staph) infections?Staphylococcus (staph) is a group of bacteria. There are more than 30 types. A type called Staphylococcus aureus causes most infections.Staph bacteria can cause many different types of infections, including:Skin infections, which are the most common types of staph infections.Bacteremia, an infection of the bloodstream. This can lead to sepsis, a very serious immune response…